PIIINP Recombinant Rabbit mAb (SDT-149-57)
PIIINP Recombinant Rabbit mAb (SDT-149-57)
Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | PIIINP |
| Synonyms | Procollagen III N-terminal propeptide |
| Immunogen | Recombinant Protein |
| Accession | P02461 |
| Clone Number | SDT-149-57 |
| Antibody Type | Recombinant mAb |
| Application | Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | Does not recognize PINP, Laminin, Collagen IV |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | >95% by HPLC |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| Sandwich ELISA | N/A |
Background
Procollagen III N-terminal propeptide (PIIINP) is cleaved from procollagen III during collagen synthesis. Thus, circulating PIIINP increases during stimulation of collagen synthesis, and serum-PIIINP can be useful in the diagnosis and monitoring of a range of diseases characterised by increased collagen III deposition. PIIINP as a single marker is currently used in Denmark for monitoring disease activity in scleroderma and methotrexate-induced liver fibrosis. Besides, PIIINP forms part of the Elevated Liver Fibrosis (ELF) test, together with hyaluronic acid and tissue inhibitor of metalloproteinases (TIMP)-1, which has been demonstrated to be sensitive for alcoholic liver fibrosis.
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