Flow cytometric analysis of 10ng/ml lipopolysaccharide and 1μg/ml BFA cultured human PBMC (human peripheral blood mononuclear cell) labelling human IL-8 antibody at 1/2000 dilution (0.1 μg) / (Right Panel) compared with a Mouse IgG2b Isotype control (Left Panel). Goat Anti - Mouse IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD14 - Brilliant Violet 510™ separately. Gated on total viable cells.
Mouse Anti-Human IL-8 Antibody (S-2875)
Mouse Anti-Human IL-8 Antibody (S-2875)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | IL-8 |
| Synonyms | Interleukin-8; IL-8; C-X-C motif chemokine 8; Chemokine (C-X-C motif) ligand 8; Emoctakin; Granulocyte chemotactic protein 1 (GCP-1); Monocyte-derived neutrophil chemotactic factor (MDNCF); IL8; CXCL8 |
| Location | Secreted |
| Accession | P10145 |
| Clone Number | S-2875 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b |
| Application | ICFCM |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| ICFCM | 1:2000 | Hu |
Background
Interleukin-8 (IL-8), also known as CXCL8, is a small 8–10 kDa chemokine produced by monocytes, macrophages, endothelial cells, and epithelial cells in response to inflammatory stimuli such as TNF-α, IL-1β, or bacterial LPS; it acts primarily through the G-protein-coupled receptors CXCR1 and CXCR2 on neutrophils to induce rapid chemotaxis, degranulation, and respiratory burst, thereby orchestrating acute inflammatory responses, angiogenesis, and tumor microenvironment remodeling, while dysregulated IL-8 expression is implicated in chronic inflammatory diseases, COPD, atherosclerosis, cancer progression, and metastasis.
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