Immobilized BCMA/TNFRSF17 His Tag Protein, Human (Cat. No. UA010083) at 2 μg/mL (100 μL/well) can bind Human TNFSF13B/BAFF/CD257 Protein, hFc tag with EC50 of 1.9-2.3 ng/ml.
Human TNFSF13B/BAFF/CD257 Protein, hFc tag
Human TNFSF13B/BAFF/CD257 Protein, hFc tag
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Tumor necrosis factor ligand superfamily member 13B, B lymphocyte stimulator (BLyS), B-cell-activating factor, BAFF, Dendritic cell-derived TNF-like molecule, TNF- and APOL-related leukocyte expressed ligand 1 (TALL-1), CD257, TNFSF13B, BAFF, BLYS, TALL1, TNFSF20, ZTNF4 |
| Accession | Q9Y275 |
| Amino Acid Sequence | Protein sequence (Q9Y275, Ala134-Leu285, with N-hFc tag) AVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 43.1 kDa Observed MW: 45 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | with N-hFc tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
BAFF is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFF-R. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. As an immunostimulant, BAFF is necessary for maintaining normal immunity. Inadequate level of BAFF will fail to activate B cells to produce enough immunoglobulin and will lead to immunodeficiency. Excessive level of BAFF causes abnormally high antibody production, results in systemic lupus erythematosus, rheumatoid arthritis, and many other autoimmune diseases. Overexpression of BAFF also correlates with enhanced humoral immunity against malaria infection.
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Bioactivity
SDS-PAGE
2μg（R: reducing conditions）
