Immobilized Human FSH alpha&FSH beta/CGA&FSHB protein, No tag&His tag at 2 μg/mL (50 μL/well) can bind FSHB Recombinant Rabbit mAb (SDT-R287) (Cat. No. S0B2272) with EC50 of 22-38 ng/mL.
Human FSH alpha&FSH beta/CGA&FSHB protein, No tag&His tag
Human FSH alpha&FSH beta/CGA&FSHB protein, No tag&His tag
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Follicle Stimulating Hormone, Follitropin, FSH |
| Accession | P01215、P01225 |
| Amino Acid Sequence |
Protein sequence1 (P01215, Ala25-Ser116) APDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVTVMGGFKVENHTACHCSTCYYHKS; Protein sequence2 (P01225, Asn19-Glu129, with C-His tag) NSCELTNITIAIEKEECRFCISINTTWCAGYCYTRDLVYKDPARPKIQKTCTFKELVYETVRVPGCAHHADSLYTYPVATQCHCGKCDSDSTDCTVRGLGPSYCSFGEMKE |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 10.2 kDa(CGA)&14.2 kDa(FSHB)；Observed MW: 20-25 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | with C-His tag (FSHB)&No tag (CGA) |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
Follicle-stimulating hormone (FSH) is a gonadotropin, a glycoprotein polypeptide hormone. FSH is synthesized and secreted by the gonadotropic cells of the anterior pituitary gland and regulates the development, growth, pubertal maturation, and reproductive processes of the body. FSH and luteinizing hormone (LH) work together in the reproductive system. FSH is a 35.5 kDa glycoprotein heterodimer, consisting of two polypeptide units, alpha and beta. The alpha subunits of the glycoproteins LH, FSH, TSH, and hCG are identical and consist of 96 amino acids, while the beta subunits vary. Both subunits are required for biological activity. FSH has a beta subunit of 111 amino acids (FSH β), which confers its specific biologic action, and is responsible for interaction with the follicle-stimulating hormone receptor. The sugar portion of the hormone is covalently bonded to asparagine, and is composed of N-acetylgalactosamine, mannose, N-acetylglucosamine, galactose, and sialic acid.
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Bioactivity
SDS-PAGE
2 μg（R: reducing conditions; NR: non-reducing conditions）
