Immobilized SIRP-α His Tag, Human (UA010009) at 20 μg/mL (50 μL/well) can bind Human CD47, hFc tag with EC50 of 12.25-18.23 ng/mL.
Human CD47, hFc tag
Human CD47, hFc tag
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Antigenic surface determinant protein OA3, Integrin-associated protein (IAP), Protein MER6, MER6 |
| Accession | Q08722 |
| Expression System | HEK293 |
| Molecular Weight | Theoretical:40kDa Actual:65kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/mg |
| Tag | with C-hFc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, 1mM EDTA, pH7.4. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα). CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers, and more recently, for the treatment of pulmonary fibrosis. CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. Furthermore, it plays a key role in immune and angiogenic responses. CD47 is ubiquitously expressed in human cells and has been found to be overexpressed in many different tumor cells. Expression in equine cutaneous tumors has been reported as well.
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Bioactivity
SDS-PAGE
2μg（R: reducing conditions）
