2μg（R: reducing conditions）
Felis CD21 Protein, His tag
Felis CD21 Protein, His tag
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Product Details
Product Details
Product Specification
| Synonyms | Complement C3d receptor 2, CR2 |
| Accession | M3WDJ8 |
| Amino Acid Sequence | Protein sequence (M3WDJ8, Ile21-Pro1038, with C-His tag) ISCDPPPPIKNGWSSYSSGPIPLNTVIRYTCSGNFRLIGERVIFCISKDQVKAIWDKGAPVCEYYNKNSFCSEPIVPGGYRDKTSRPPYRHGDSVTFTCNTNFTMKGNKSVWCRANRTWGPTPLPICESDFPQECTSLPKIPNGHHTGESVGSFAPGLSVTYSCEPGYLLVGEKTIRCLSSGKWSAAFPGCKEAQCEPPGPFLNGEIEGPPSLRVGVTVNFYCNEGYWLQGQPSSRCVIAGQRASWTRMPVCKEILCGPPPSILNGRHTGNPSGNIPYGSMVTYACDPDPEKGVSFILTGKKTIHCTANSQKTGGVWSGPAPRCELSSSAIQCPPPQIPRGHISSGWKEQYSYNDTVVFACTFGFTMKGSKVTRCNGQGAWEPSVPVCEKECQAPPKILNGQKEDGHMVRFDPGTSIKYRCDPGYVLVGEKSIRCTSEGVWTPTAPECKVAECEPIEKQVFKRPRDQFIRPDVNSSCDEGYRLGGSVYQLCQGAIPWFMEHRLCEEITCPPPPVIYNGKHTRSSSENVPYGTTVTYTCNPGPESGVEFILVGESTIRCISNDQERGIWSGPAPVCKLSLPAVQCPPAHVANGYKISGKEAPYFYNDSVTFKCNKGFTLKGSSQIRCKANNTWDPEIPVCEKGCPPPFGLQHGRHTGGNRVLFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCEEAPCQPVREDLREPPVHSHVVLVNTSCQEGYQLTGHAYQKCQDAENRVWFQKIPLCKAVHCPPPPVIDHGRPRGVMAEHFLYGNEVSYECDQGFSLLGEKNIRCISDSKGHGSWSGPTPQCFKSPPVTHCPNPEVKHGYKLNKTRSSYAHNDTVYVACNPGFIMNGSNLIRCHTSNQWVPGVPTCIKMAFSGCQPPLDIPNGNHTGGDMARFSPGMSILYSCDQGYLLVGEAFLLCTHEGTWSQPAPYCKEVNCSSPEYINGIQKGLEPGKMYQYGAIVTLECEEGYTLEGSPQSQCQDDHRWNPPLAVCKSPASLAP |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 113.1 kDa Observed MW: 160 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | with C-His tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
Complement receptor type 2 (CR2), also known as complement C3d receptor, Epstein-Barr virus receptor, and CD21 (cluster of differentiation 21), is a protein that in humans is encoded by the CR2 gene. CR2 is involved in the complement system. It binds to iC3b (inactive derivative of C3b), C3dg, or C3d. B cells express CR2 receptors on their surfaces, allowing the complement system to play a role in B-cell activation and maturation. Complement receptor 2 interacts with CD19, and, on mature B cells, forms a complex with CD81 (TAPA-1). The CR2-CD19-CD81 complex is often called the B cell co-receptor complex, because CR2 binds to opsonized antigens through attached C3d (or iC3b or C3dg) when the B-cell receptor binds antigen. This results in the B cell having greatly enhanced response to the antigen.
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