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ENPP3/CD203c Fc Chimera Protein, Mouse

ENPP3/CD203c Fc Chimera Protein, Mouse

Catalog Number: UA011114 Reactivity: Mouse Conjugation: Unconjugated Brand: UA BIOSCIENCE
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Regular price $256 USD
Regular price Sale price $256 USD
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Product Details

Product Specification


Species Mouse
Synonyms EC:3.1.4.1,E-NPP 3,PD-Ibeta,NPPase,CD203c,PDNP3,Phosphodiesterase I/nucleotide pyrophosphatase 3,Nucleotide diphosphatase,ENPP3,DJ914N13.3 (Phosphodiesterase I/Nucleotide Pyrophosphatase 3),Phosphodiesterase-I Beta,Phosphodiesterase I Beta,CD203c Antigen,Gp130RB13-6,NPP3,B10,Ectonucleotide pyrophosphatase/phosphodiesterase family member 3,Ectonucleotide Pyrophosphatase/Phosphodiesterase 3,DJ1005H11.3 (Phosphodiesterase I/Nucleotide Pyrophosphatase 3),EC:3.6.1.9
Accession Q6DYE8
Amino Acid Sequence

Arg46-Ile874 with Human IgG1 Fc Tag at N-Terminus

Expression System HEK293
Molecular Weight 110-150kDa (Reducing)
Purity >95% by SDS-PAGE &>90% by SEC-HPLC
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag Human IgG1 Fc
Physical Appearance Lyophilized Powder
Storage Buffer PBS, PH7.4, 5% trehalose
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Yao, Wang, Han et al.[J] J Transl Med. (2023) 21 (1), 594.

Background

ENPP3 (CD203c, ENPP3) is a member of the human NPP (Nucleotide Pyrophosphatase/Phosphodiesterase) family. It is expressed in various organs, including on epithelial and mucosal surfaces, and is particularly notable on basophils and mast cells. NPP3 serves as a common marker for diagnosing allergen sensitivity by analyzing patient basophils using flow cytometry.
Basophils and mast cells play a role in mediating responses to certain pathogens as well as acute and chronic allergic reactions. Upon activation, these cells release ATP, which further stimulates them in an autocrine manner. The upregulation of NPP3 helps to degrade ATP and suppresses chronic allergic inflammation, without affecting the acute response.

Picture

SDS-PAGE

1μg (R: reducing condition).

SEC-HPLC

The purity of ENPP3/CD203c Fc Chimera Protein, Mouse is greater than 90% as determined by SEC-HPLC.

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