1μg (R: reducing condition, N: non-reducing condition).
CXADR/CAR His Tag Protein, Human
CXADR/CAR His Tag Protein, Human
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$200 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | CXADR, CAR, CAR4/6, HCAR |
| Accession | NP_001329.1 |
| Amino Acid Sequence | Leu20-Gly237 with His Tag at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 30-33kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & SEC-HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Seuthe IMC, Krause L, Ruwe M, Silling S, Ehrhardt A, Eichhorn S, Ehrke-Schulz E, Park JJ. Expression and prognosis of DSG-2, CXADR, CD46 in head and neck squamous cell carcinoma. Pathol Res Pract. 2024 Oct; 262:155541. |
Background
Coxsackie virus and adenovirus receptor (CXADR), also known as CAR, is a type I transmembrane glycoprotein that serves as a receptor for group B coxsackie viruses and subgroup C adenoviruses. It belongs to the CTX family within the immunoglobulin (Ig) superfamily. CAR is strongly expressed in the developing central nervous system and functions as both a homophilic and heterophilic cell adhesion molecule through its interactions with extracellular matrix glycoproteins, including fibronectin, agrin, laminin-1, and tenascin-R.
The human CXADR protein consists of a signal sequence, an extracellular domain (ECD) with a V-type (D1) and a C2-type (D2) Ig-like domain, a transmembrane segment, and an intracellular domain. The D1 domain is believed to be responsible for homodimer formation within tight junctions and is necessary and sufficient for adenovirus binding. Variants of CXADR are anchored to the cell membrane by a glycosylphosphatidylinositol (GPI) anchor.
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SDS-PAGE
SEC-HPLC
The purity of CXADR/CAR His Tag Protein, Human is more than 95% determined by SEC-HPLC.
