• TMEM119 Fc Chimera Protein, Human
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TMEM119 Fc Chimera Protein, Human

TMEM119 Fc Chimera Protein, Human

Catalog Number: UA010710 Reactivity: Human Conjugation: Unconjugated Brand: UA BIOSCIENCE
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$724 USD
$724 USD
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Product Details

Product Specification


Species Human
Synonyms TMEM119,OBIF
Accession Q4V9L6
Amino Acid Sequence Arg26-Met96, with C-hIgG1 Fc
Expression System HEK293
Molecular Weight 37-50kDa (Reducing)
Purity ＞95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag Human Fc Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4.
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Jiang, Z,H. et al. (2017) Expt & Mol Med. 49:e329. 2.Satoh, J. et al. (2016) Neuropathol. 36:39.

Background

TMEM119 (Transmembrane Protein 119, also known as Osteoblast Induction Factor or OBIF), is an approximately 38-kDa type 1 transmembrane protein. Mature human TMEM119 consists of a 71 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 166 aa cytoplasmic domain. It is predominantly expressed in osteoblasts and is upregulated during osteoblastic differentiation. TMEM-119 is involved in the osteoblast differentiation and bone development by acting as a ligand and has been reported to contribute to the proliferation, migration, and invasion of osteosarcoma cells, as well as functioning as an oncogene in osteosarcoma.

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SDS-PAGE

1μg (R: reducing condition, N: non-reducing condition).