Lactylation Modification Orchestrates Metabolic Reprogramming and Innate Immune Regulation
22 Apr 2026
by AntBio
Lactylation Modification Orchestrates Metabolic Reprogramming and Innate Immune Regulation
1. Literature Information
Title: Lactylation antibody: How to reveal the novel molecular mechanisms of metabolic reprogramming regulating innate immunity?
Core theme: Lactylation serves as a critical post-translational modification linking metabolic reprogramming to innate immune suppression, with AARS1/2 as key regulators and cGAS as a major target.
Field: Immunometabolism, post-translational modifications, innate immune signaling
2. Research Background
Lactate, once regarded as a metabolic waste product, is now recognized as a vital signaling metabolite in the tumor microenvironment, inflammatory reactions, and cellular stress responses. Accumulating evidence indicates that lactate can trigger protein lactylation, a newly identified post-translational modification that profoundly modulates immune cell functions. Hyperlactatemia is clinically associated with immunosuppression and reduced interferon production, yet the underlying molecular machinery remained undefined.
3. Research Approach
The research employed genome-wide CRISPR screening, biochemical assays, structural biology, and animal models to identify lactate-sensing enzymes, characterize lactylation catalysis, and define downstream effects on innate immune sensors. Lactylation-specific antibodies enabled precise detection of endogenous modification levels during immune regulation.
4. Research Outcomes
- AARS1/2 as bifunctional enzymes: AARS1 and AARS2 act as both alanine-tRNA ligases and lactate sensors that catalyze protein lactylation in an ATP-dependent manner.
- Molecular mechanism: Lactate competes with alanine at the enzyme active site, driving lysine lactylation on target proteins including cGAS.
- cGAS functional inhibition: Lactylation of cGAS strongly reduces DNA-binding capacity, impairs phase separation, and abolishes cGAMP synthesis, causing innate immune suppression.
- Pathological relevance: This pathway mediates lactate-induced immune evasion during viral infection and tumorigenesis.
5. Product Empowerment by ANT BIO PTE. LTD.
ANT BIO provides L-Lactyl Lysine Rabbit Polyclonal Antibody (Cat. No. S0B0719), a high‑specificity tool validated for WB, IP, and IF applications. This reagent enables robust detection of endogenous lactylation events, supporting mechanistic studies in immunometabolism, epigenetic regulation, and disease-related research.
6. Brand Mission
ANT BIO PTE. LTD. is a trusted provider of premium life science reagents, including antibodies, proteins, assay kits, and general laboratory reagents. Our sub‑brands — Absin (general reagents & kits), Starter (antibodies), and UA (recombinant proteins) — support cutting‑edge research worldwide.
7. Related Product List
- L-Lactyl Lysine Rabbit Polyclonal Antibody (S0B0719)
- Lactylation modification research tool kit
- Immunometabolism antibody panel
- cGAS pathway research reagents
Brand Promotion
ANT BIO PTE. LTD. – Empowering Scientific Breakthroughs
At ANTBIO, we are committed to advancing life science research through high-quality, reliable reagents and comprehensive solutions. Our specialized sub-brands (Absin, Starter, UA) cover a full spectrum of research needs, from general reagents and kits to antibodies and recombinant proteins. With a focus on innovation, quality, and customer-centricity, we strive to be your trusted partner in unlocking scientific mysteries and driving medical progress. Explore our product portfolio today and elevate your research to new heights.
