Measured by its ability to induce IL-17 secretion by mouse splenocytes. The EC50 for this effect is 0.051 ng/mL.
IL-23 Protein, Rat
IL-23 Protein, Rat
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Product Details
Product Details
Product Specification
| Species | Rat |
| Synonyms | SGRF, IL-23p19, CLMF p40, IL-12 subunit p40, NKSF2, IL-23, Interleukin-23 |
| Accession | p19: Q91Z84、p40: Q9R278 |
| Amino Acid Sequence | p19: Val22-Ala196, with His Tag at N-terminus |
| Expression System | HEK293 |
| Molecular Weight | 20-22, 40-45 kDa (Reducing) |
| Purity | >95% by SDS-PAGE. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, 5% trehalose, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.·3 months, -20 to -80℃ under sterile conditions after reconstitution.·1 week, 2 to 8℃ under sterile conditions after reconstitution.·Please avoid repeated freeze-thaw cycles. |
| Reference | Immunity 2000, 13(5):715-725. |
Background
Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naive and memory human T cells, the effects of IL-23 is restricted to memory T cells.
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Bioactivity
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
