Nectin-3/CD113 Fc Chimera Protein, Human
Nectin-3/CD113 Fc Chimera Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Poliovirus Receptor-Related Protein 3; CDw113; Nectin-3; CD113; PVRL3; PRR3 |
| Accession | Q9NQS3 |
| Amino Acid Sequence | Gly58-Asp400, with C-terminal Human Fc |
| Expression System | HEK293 |
| Molecular Weight | 85-95kDa(reducing） |
| Purity | ＞95%, by SDS-PAGE under reducing conditions |
| Endotoxin | <0.2EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation . |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
NECTIN3, also known as Nectin Cell Adhesion Molecule 3, is part of the nectin family. NECTIN3 is intended to initiate cell-cell adhesion to stimulate cell attachment and to allow subsequent formation of JAM-and cadherin-based intercellular junctions. NECTIN3 induces endocytosis-mediated down-regulation of PVR from the cell surface, which results in reduction of cell movement & proliferation. Following Nectin-3 activity adds strength to the junction through trans-interaction with various molecules.
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Bioactivity
Anti-His antibody Immobilized on CM5 Chip captured Nectin-1 His Tag, Human (Cat. No. UA010017), can bind Nectin-3 Fc Chimera, Human(Cat. No. UA010019) with an affinity constant of 17.31 nM as determined in SPR assay.
SDS-PAGE
Nectin-3/CD113 Fc Chimera, Human，1μg on SDS-PAGE under reducing and Non-reducing condition. The purity is greater than 95%.
