1μg (R: reducing condition, N: non-reducing condition).
GDF-15 Protein, Human
GDF-15 Protein, Human
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$134 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB, NRG-1 |
| Accession | Q99988 |
| Amino Acid Sequence | Ala197-Ile308, with N-terminal Human IgG Fc |
| Expression System | HEK293 |
| Molecular Weight | 38-42kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Review Front Immunol . 2020 May 19;11:951. eCollection 2020. |
Background
Growth differentiation factor 15 (GDF-15) is a polypeptide hormone belonging to the transforming growth factor β (TGF-β) superfamily. GDF-15 is highly expressed in placenta and is expressed at lower levels in kidney, pancreas, prostate and colon. Similarly to other TGF-beta family proteins, GDF-15 is synthesized as a large precursor protein that is cleaved at the dibasic cleavage site (RXXR) to release the carboxy-terminal domain. GDF-15 has been studied to have a wide range of biological functions in physiology and pathology, especially in aging, cancer, and metabolic processes.
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SDS-PAGE
ELISA
Measured in a cytotoxicity assay using Balb/c 3T3 mouse fibroblast cells, the EC50 for this effect is less than 5ng/ml.
