TRPA1 Flag Tag full length protein, Human(nanodisc)
TRPA1 Flag Tag full length protein, Human(nanodisc)
Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | ANKTM1,FEPS,FEPS1 |
| Accession | O75762 |
| Expression System | HEK293 |
| Molecular Weight |
127.5 kDa
|
| Conjugation | Unconjugated |
| Tag | Flag Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20 mM Tris-HCl, 150 mM NaCl, pH 8.0. Normally 5% – 8% trehalose is added as protectants before lyophilization |
| Stability & Storage |
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Background
The structure of the protein is highly related to both the protein ankyrin and transmembrane proteins. This protein is activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds. Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner, whereas mechanisms of non-electrophilic ligands are not well determined. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system.
