2e5 of transient transfected anti- CD19 ScFv CAR-293 cells were stained with 0.01ug PE-Labeled CD19 His Tag Protein, Human, (Cat. No. UA011320) and unlable respectively (Fig. C and B), and non-transfected 293 cells were used as a control (Fig. A). PE signal was used to evaluate the binding activity.
2e5 of transient transfected anti- CD19 ScFv CAR-293 cells were stained with isotype and Whitlow/218 Linker-Alexa Fluor® 488 (Fig. D and E). Alexa Fluor® 488 signal was used to evaluate the binding activity.
PE-Labeled CD19 His Tag Protein, Human
PE-Labeled CD19 His Tag Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | CD19,B4,CVID3,MGC12802 |
| Accession | P15391-1 |
| Amino Acid Sequence | Pro 20-Lys 291 with His Tag at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 40-45kDa (Reducing) |
| Conjugation | PE |
| Tag | His Tag |
| Physical Appearance | Liquid |
| Storage Buffer | PBS 0.5%BSA pH7.4 |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Wang SY, An WH, Wang ZS, Wang WL, Zhang B, Xu KL, Guo SL, Gao M, Li B, Huang L, Tian HH, Guo WY, Wang HR. Incidentally cured psoriasis in a patient with refractory/relapsed diffuse large B-cell lymphoma receiving CD19 CAR-T cell therapy: a case report. Front Immunol. 2024 Oct 24; 15: 1418768. |
Background
CD19, also known as B-lymphocyte antigen or Cluster of Differentiation 19, is a single-pass type I membrane protein that contains two Ig-like C2-type (immunoglobulin-like) domains. It is expressed on follicular dendritic cells and B cells, being present from the earliest recognizable B-lineage cells during development to B-cell blasts, but is lost upon maturation to plasma cells. CD19 primarily functions as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, leading to binding by Src-family kinases and recruitment of PI-3 kinase. Mutations in the CD19 gene are associated with severe immunodeficiency syndromes, characterized by diminished antibody production. CD19 has been shown to interact with CD81, CD82, Complement receptor 2, and VAV2.
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