1μg (R: reducing condition, N: non-reducing condition).
Nectin-4 His Tag Protein, Rat
Nectin-4 His Tag Protein, Rat
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$604 USD
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Product Details
Product Details
Product Specification
| Species | Rat |
| Synonyms | PRR4，LNIR，Nectin cell adhesion molecule 4，PVRL4，Ig superfamily receptor LNIR，Poliovirus receptor-related protein 4，NECTIN4，Poliovirus Receptor-Related 4，Nectin-4，Nectin 4，EDSS1 |
| Accession | D3ZET1 |
| Amino Acid Sequence | Tyr28-Val348, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 40-42kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Reymond, N. et al. (2001) J. Biol. Chem. 276:43205. 2.Takai, Y. et al. (2008) Nat. Rev. Mol. Cell Biol. 9:603. 3.Fabre, S. et al. (2002) J. Biol. Chem. 277:27006. |
Background
Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. Nectin extracellular domains (ECDs) contain three Ig-like domains: an N-terminal V-type that mediates ligand binding, and two C2-type .Human Nectin-4 is normally expressed in the placenta, especially in endothelial cells, while in the mouse it is found in the embryo, lung, testis and brain. In humans, mutation of Nectin-4 has been correlated with ectodermal dysplasia-syndactyly syndrome,High Nectin-4/PVRL4 expression was associated with poor-prognosis in some invasive breast cancers and may be a new promising prognostic biomarker and specific therapeutic target.
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SDS-PAGE
ELISA
Immobilized Nectin-4 His Tag Protein, Rat (Cat. No. UA010687) at 2.0μg/mL (100μL/well) can bind Anti-Human Nectin-4 (Enfortumab) with EC50 of 1.17-2.09ng/mL.
