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MIS RII Llama IgG2b Fc Chimera Protein, Human

MIS RII Llama IgG2b Fc Chimera Protein, Human

Catalog Number: UA011293 Brand: UA BIOSCIENCE
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$281.00 SGD
$281.00 SGD
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Product Details

Product Specification


Species Human
Synonyms MRII,AMHR2,AMHR,MISR2,MIS type II receptor,MISRII
Accession Q16671-1
Amino Acid Sequence

Pro18-Ser144 with Llama IgG2b Fc Tag at the C-Terminus
Expression System HEK293
Molecular Weight 55-72kDa (Reducing)
Purity ＞90% by SDS-PAGE
Conjugation Unconjugated
Tag Llama IgG2b Fc Tag
Physical Appearance Lyophilized Powder
Storage Buffer

PBS, PH7.4, 5% trehalose
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Tanaka S, Mori M, Mafune K, Ohno S, Sugimachi K. A dominant negative mutation of transforming growth factor-beta receptor type II gene in microsatellite stable oesophageal carcinoma. Br J Cancer. 2000 May;82(9):1557-60.
2.Mohri Y, Shimizu M, Fujimoto T, Nishikawa Y, Ikeda A, Matsuda Y, Wada T, Kawaguchi C. A young child with pediatric multisystem inflammatory syndrome successfully treated with high-dose immunoglobulin therapy. IDCases.

Background

The Anti-Müllerian Hormone Type II Receptor (AMHRII/MISRII) is a single-transmembrane serine/threonine kinase receptor within the TGF-beta superfamily that, upon binding its ligand, forms a complex with type I and type II kinases to initiate a phosphorylation-dependent signaling cascade. This pathway ultimately activates SMAD transcription factors and mediates Müllerian duct regression in male embryos. Mutations in this receptor cause Persistent Müllerian Duct Syndrome (PMDS), a disorder in genetic males characterized by the development of female reproductive tract structures, though the specific mechanism of AMHR2 gene activation remains incompletely understood. The recombinant human AMHR2/MISRII protein produced in HEK293 cells with a C-terminal Llama Fc tag is used for research purposes.

Picture

SDS-PAGE

2μg (R: reducing condition, N:non-reducing condition).