Eotaxin-3/CCL26 Protein, Human
Eotaxin-3/CCL26 Protein, Human
Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | CC chemokine IMAC,MIP-4-alpha,Small-inducible cytokine A26,Thymic stroma chemokine-1 (TSC-1) |
| Accession | Q9Y258 |
| Amino Acid Sequence | Thr24-Leu94 |
| Expression System | E.coli |
| Molecular Weight | Approximately 8.4 kDa, a single non-glycosylated polypeptide chain containing 71 amino acids. |
| Purity | ＞97% by SDS-PAGE or HPLC. |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | 20 mM PB, with 150 mM NaCl, pH 7.4. |
| Reconstitution | Before use this product, please read the direction below carefully. This vial must be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in a sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions. |
| Stability & Storage | For long term storage, the product should be stored ≤ -20℃. |
Background
Eotaxin-3 is a CC chemokine that signals through the CCR3 receptor. It is produced by endothelial cells stimulated with IL-4 or IL-13. Eotaxin-3 selectively targets cells expressing CCR3, including eosinophils, basophils, T cells and monocytes. Eotaxin-3 has similar activity to Eotaxin and Eotaxin-2, but the three Eotaxins share only a low degree of sequence homology. CCL26 elicits its effects activity by binding to the cell surface chemokine receptor CCR3, and chemotactic for eosinophils and basophils. Recombinant Human Eotaxin-3 is an 8.4kDa protein containing 71 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
