2μg (R: reducing condition, N:non-reducing condition).
Biotinylated IL-6R alpha/CD126 Fc&Avi Tag Protein, Human
Biotinylated IL-6R alpha/CD126 Fc&Avi Tag Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | IL6R,IL-6R-1,IL-6RA,IL6RA,IL-6R-alpha,IL6RQ,gp80 |
| Accession | P08887 |
| Amino Acid Sequence | Leu20-Pro365 with Fc&Avi at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 72-95kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & > 90% SEC-HPLC |
| Conjugation | Biotin |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.He Q, Cheng R, Shi J, Na T, Wang Q, Ochir S. Preparation and in vitro Immunoreactivity of Rosa rugosa Polysaccharide Liposomes. Iran J Pharm Res. 2025 Aug 25;24(1):e161557. |
Background
The interleukin-6 receptor (IL-6R/CD126) is a type I cytokine receptor existing in membrane-bound and soluble forms. The functional receptor complex comprises the ligand-binding IL-6R subunit and the signal-transducing glycoprotein 130 (gp130). IL-6 signaling occurs through two distinct pathways: classic signaling via membrane-bound IL-6R and trans-signaling mediated by the soluble IL-6R (sIL-6R), which is generated through proteolytic cleavage. This trans-signaling mechanism enables IL-6 to act on cell types lacking membrane-bound IL-6R by forming complexes with sIL-6R that activate gp130. The IL-6R system regulates immune responses, cell growth, and differentiation, but its dysregulation is implicated in various chronic inflammatory diseases, autoimmune disorders, and malignancies. Consequently, therapeutic targeting of this pathway, particularly through humanized anti-IL-6R monoclonal antibodies, represents a promising approach for treating IL-6-driven pathologies.
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SDS-PAGE
SEC-HPLC
The purity of Biotinylated IL-6R alpha/CD126 Fc&Avi Tag Protein, Human is more than 90% determined by SEC-HPLC.
ELISA
Immobilized Human IL-6 (Cat. No. S0A4038) at 5.0μg/mL (100μL/well) can bind Biotinylated IL-6R alpha/CD126 Fc&Avi Tag Protein, Human (Cat. No. UA011318) with EC50 of 10.92-19.84ng/mL.
