Flow cytometric analysis of BALB/c mouse splenocytes labelling Mouse FR4 antibody at 1/200 (1 μg) dilution/ (Right panel) compared with a Rat IgG1, κ Isotype Control / (Left panel). Goat Anti-Rat IgG Alexa Fluor® 647 was used as the secondary antibody. Cells were stained with CD4 - APC/Cy7 Antibody separately.
Rat Anti-Mouse FR4 Antibody (S-R705)
Rat Anti-Mouse FR4 Antibody (S-R705)
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | FR4 |
| Synonyms | Sperm-egg fusion protein Juno; Folate receptor 4; Folate receptor delta (FR-delta); Folate-binding protein 3; IZUMO1 receptor protein JUNO; Izumo1r; Folbp3; Folr4; Juno |
| Location | Cell membrane |
| Accession | Q9EQF4 |
| Clone Number | S-R705 |
| Antibody Type | Rat mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse splenocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:200 | Ms |
Background
Folate receptor 4 (FR4), also known as FOLR4, is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein belonging to the folate receptor family. It is primarily expressed in the immune system, particularly in regulatory T cells (Tregs) and certain B cell subsets. The function of FR4 has not been fully elucidated, but studies suggest it may play a role in immune regulation and cell signaling. Unlike other members of the family (e.g., FRα, FRβ), FR4 has a lower affinity for folate, indicating it may have unique biological functions. Additionally, FR4 expression is associated with certain cancers and autoimmune diseases, potentially serving as a diagnostic marker or therapeutic target. Research is ongoing to explore its specific mechanisms and clinical applications.
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