Peripherin Rabbit Polyclonal Antibody

Peripherin is a 57 kDa type III intermediate filament (IF) protein selectively expressed in the peripheral and enteric nervous systems, where it co-assembles with other IF subunits to form a dynamic scaffold that maintains neuronal shape, supports axonal outgrowth during development and regeneration, and provides resilience against mechanical stress; its expression is markedly up-regulated after axonal injury, making it a widely used marker of neuroplasticity, and pathogenic mutations or deranged aggregation of peripherin has been implicated in motor-neuron degenerative diseases such as amyotrophic lateral sclerosis.