Mouse IL-4 Recombinant Rabbit mAb (S-3687)
Mouse IL-4 Recombinant Rabbit mAb (S-3687)
Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | IL-4 |
| Clone Number | S-3687 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | ELISA |
| Reactivity | Ms |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| ELISA | 1:5000-1:10000 | Ms |
Background
Mouse interleukin-4 (IL-4) is an 18–20 kDa monomeric glycoprotein cytokine primarily produced by Th2 cells, mast cells, basophils, eosinophils, NKT cells, and γδT cells. As a central regulator of type 2 immunity, it drives Th2 differentiation via the JAK-STAT6 pathway upon binding to IL-4 receptor complexes (IL-4Rα paired with γc or IL-13Rα1), inducing transcription factors like GATA3 and c-Maf. Functionally, IL-4 promotes B cell proliferation, class switching to IgG1/IgE, and activation of eosinophils/mast cells, while suppressing Th1 responses. Its roles are context-dependent: IL-4 exerts protective effects in acute lung injury (reducing TNF-α/IL-6 and apoptosis) and cerebral ischemia (attenuating neuroinflammation), yet can exacerbate infections (e.g., mousepox) by suppressing cytolytic lymphocyte responses.
