Unstimulated / (Left panel) and 10 μg/ml phytohemagglutinin (PHA)-stimulated (2 days) / (Right panel) peripheral blood mononuclear cells were stained with Human CD134 at 1/200 dilution (1 μg) / (Right panel). Goat Anti-Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD3 - Alexa Fluor® 647 antibody separately.
Mouse Anti-Human CD134 Antibody (S-R589)
Mouse Anti-Human CD134 Antibody (S-R589)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD134 |
| Synonyms | Tumor necrosis factor receptor superfamily member 4; ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; TXGP1L; TNFRSF4 |
| Location | Membrane |
| Accession | P43489 |
| Clone Number | S-R589 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human peripheral blood mononuclear cells |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD134, also known as OX40 or tumor necrosis factor receptor superfamily member 4 (TNFRSF4), is a type 1 transmembrane glycoprotein and a secondary co-stimulatory immune checkpoint molecule involved in long-term T cell immunity. It is transiently expressed on activated CD4+ and CD8+ T cells after T cell receptor (TCR) ligation. The interaction between CD134 and its ligand, OX40L, enhances T cell activation, proliferation, survival, and cytokine production. CD134 is crucial for maintaining an immune response beyond the initial activation phase and is being investigated as a target in cancer immunotherapy, autoimmune disease modulation, and vaccine development.
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