Product Specification
| Host |
Rabbit |
| Antigen |
LDL Receptor |
| Synonyms |
Low-density lipoprotein receptor, LDLR |
| Immunogen |
Synthetic Peptide |
| Location |
Golgi Apparatus, Lysosome, Endosome, Plasma Membrane |
| Accession |
P01130 |
| Clone Number |
SDT-057-57 |
| Antibody Type |
Rabbit mAb |
| Application |
WB, IHC-P |
| Reactivity |
Hu, Ms, Rt |
| Predicted Reactivity |
Bv, Rb |
| Purification |
Protein A |
| Concentration |
0.25mg/ml |
| Physical Appearance |
Liquid |
| Storage Buffer |
PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage |
12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application |
dilution |
species |
| IHC-P |
1:1000 |
|
| WB |
1:500 |
|
Background
The low density lipoprotein receptor (LDL R) is the founding member of the LDL R family of scavenger receptors.Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis.LDLR is ubiquitously expressed and is a key receptor for maintaining cholesterol homeostasis in mammals. LDLR-mediated endocytosis is essential for lipoprotein and lipid metabolism.Impaired LDLR function by genetic mutations results in a condition with extremely elevated serum LDL levels and early onset atherosclerosis known as familial hypercholesterolemia (FH).
