Flow cytometric analysis of Mouse CD102 (ICAM-2) expression on BALB/c mouse splenocytes. BALB/c mouse splenocytes were stained with either Rat IgG2a, κ Isotype Control (Black line histogram) or SDT FITC Rat Anti-Mouse CD102 (ICAM-2) Antibody (Red line histogram) at 5 μl/test, cells without incubation with primary antibody and secondary antibody (Blue line histogram) was used as unlabelled control. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
FITC Rat Anti-Mouse CD102 (ICAM-2) Antibody (S-R724)
FITC Rat Anti-Mouse CD102 (ICAM-2) Antibody (S-R724)
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | CD102 |
| Synonyms | Intercellular adhesion molecule 2; Lymphocyte function-associated AG-1 counter-receptor; Icam-2; Icam2 |
| Location | Membrane |
| Accession | P35330 |
| Clone Number | S-R724 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5 μl per million cells in 100μl volume | Ms |
Background
CD102, also known as intercellular adhesion molecule 2 (ICAM-2), is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. It is widely expressed on resting lymphocytes, monocytes, platelets, and vascular endothelial cells. CD102 plays a crucial role in immune response by binding to leukocyte integrins such as LFA-1 (CD11a/CD18) and mediating adhesive interactions important for lymphocyte recirculation, antigen-specific immune responses, and natural killer cell-mediated clearance. Additionally, it has been identified as a biomarker for long-lived plasma cells in non-human primates and is involved in maintaining the longevity of these cells in the bone marrow. Elevated levels of CD102 have also been associated with conditions like hemorrhagic fever with renal syndrome and idiopathic pulmonary fibrosis.
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