IHC shows positive staining in paraffin-embedded mouse spleen. Anti-CD11c antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
CD11c Recombinant Rabbit mAb (S-3824)
CD11c Recombinant Rabbit mAb (S-3824)
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Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | CD11c |
| Synonyms | Integrin alpha-X; CD11 antigen-like family member C; Leu M5; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD11C; ITGAX |
| Location | Membrane |
| Accession | P20702 |
| Clone Number | S-3824 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P |
| Reactivity | Ms |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:250 | Ms |
Background
CD11c is a type I transmembrane protein and a member of the β2 integrin family, primarily expressed on dendritic cells, monocytes, macrophages, neutrophils, and some B cells. It forms a heterodimer with CD18, known as integrin αXβ2. This molecule plays a crucial role in immune cell functions such as adhesion, phagocytosis, and cell migration. CD11c is also involved in the regulation of B cell homeostasis and the development of T cells in the thymus. Additionally, it has been implicated in the clearance of apoptotic cells by microglia during developmental apoptosis.
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Immunohistochemistry
