Flow cytometric analysis of Human CD15 expression on human Peripheral Blood cells. Human Peripheral Blood cells were stained with Biotin Isotype Control (Left panel) or SDT Biotin Mouse Anti-Human CD15 Antibody (Right panel) at 5 μl/test followed by Sav-PE. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Biotin Mouse Anti-Human CD15 Antibody (S-R463)
Biotin Mouse Anti-Human CD15 Antibody (S-R463)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD15 |
| Synonyms | Sialyl LewisX (sLeX); SSEA1 |
| Location | Membrane |
| Accession | P22083 |
| Clone Number | S-R463 |
| Antibody Type | Mouse mAb |
| Isotype | IgM |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human Peripheral Blood cells |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD15, also known as Lewis X or SSEA-1, is a fucosylated carbohydrate antigen found on the surface of various cells. It is a complex cluster of cell surface glycoproteins and glycolipids with a common terminal pentasaccharide. CD15 plays a significant role in cell adhesion and migration, particularly in immune responses and development. It is expressed on most terminally differentiated myeloid cells, including granulocytes, eosinophils, and monocytes/macrophages, but not on hematopoietic progenitor cells. In addition, CD15 is found in various epithelia and neural tissues. In cancer, CD15 is present on the membrane proteins of several types of cancer cells, such as renal, prostate, and breast cancer cells. It interacts with selectins to facilitate cancer cell adhesion to endothelial cells, promoting metastasis. Therefore, CD15 has potential as a therapeutic target and prognostic marker in cancer treatment.
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