Immobilized Human YWHAQ/14-3-3 theta Protein, His Tag at 2 μg/mL (100 μL/well) can bind 14-3-3 theta Rabbit polyclonal antibody (Cat. No. S0B0624) with EC50 of 8.2-9.1 ng/ml.
Human YWHAQ/14-3-3 theta Protein, His Tag
Human YWHAQ/14-3-3 theta Protein, His Tag
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | 14-3-3 protein theta, 14-3-3 protein T-cell, 14-3-3 protein tau, Protein HS1, YWHAQ |
| Accession | P27348 |
| Amino Acid Sequence | Protein sequence (P27348, Met1-Asn245, with C-His Tag) MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKNVVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLDKYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIDNSQGAYQEAFDISKKEMQPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDSAGEECDAAEGAEN |
| Expression System | E.coli |
| Molecular Weight | Predicted MW: 29.5 kDa Observed MW: 30 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
YWHAQ, also known as 14-3-3 tau (τ), is a member of the highly conserved 14-3-3 family of phosphoserine/phosphothreonine-binding proteins. It functions as a key regulatory adapter molecule in eukaryotic cells. By binding to specific phosphorylated client proteins, YWHAQ modulates their activity, stability, subcellular localization, and participation in protein complexes. It is involved in a wide array of vital cellular processes, including signal transduction, cell cycle control, apoptosis, and metabolism. The protein plays a significant role in immune cell signaling and has been implicated in the pathogenesis of cancers and neurodegenerative diseases.
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Bioactivity
SDS-PAGE
2μg（R: reducing conditions）
