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Human SLP-76 Protein, His Tag

Human SLP-76 Protein, His Tag

Catalog Number: S0A0198 Brand: Starter
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$261.00 SGD
$261.00 SGD
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Product Details

Product Specification


Species Human
Synonyms Lymphocyte cytosolic protein 2, SH2 domain-containing leukocyte protein of 76 kDa, SLP-76 tyrosine phosphoprotein (SLP76), LCP2
Accession Q13094
Amino Acid Sequence

Protein sequence (Q13094, Met1-Pro533, with C-His Tag) MALRNVPFRSEVLGWDPDSLADYFKKLNYKDCEKAVKKYHIDGARFLNLTENDIQKFPKLRVPILSKLSQEINKNEERRSIFTRKPQVPRFPEETESHEEDNGGWSSFEEDDYESPNDDQDGEDDGDYESPNEEEEAPVEDDADYEPPPSNDEEALQNSILPAKPFPNSNSMYIDRPPSGKTPQQPPVPPQRPMAALPPPPAGRNHSPLPPPQTNHEEPSRSRNHKTAKLPAPSIDRSTKPPLDRSLAPFDREPFTLGKKPPFSDKPSIPAGRSLGEHLPKIQKPPLPPTTERHERSSPLPGKKPPVPKHGWGPDRRENDEDDVHQRPLPQPALLPMSSNTFPSRSTKPSPMNPLPSSHMPGAFSESNSSFPQSASLPPYFSQGPSNRPPIRAEGRNFPLPLPNKPRPPSPAEEENSLNEEWYVSYITRPEAEAALRKINQDGTFLVRDSSKKTTTNPYVLMVLYKDKVYNIQIRYQKESQVYLLGTGLRGKEDFLSVSDIIDYFRKMPLLLIDGKNRGSRYQCTLTHAAGYP
Expression System HEK293
Molecular Weight Predicted MW: 61.9 kDa Observed MW: 75-100 kDa
Purity ＞95% by SDS-PAGE
Endotoxin <1EU/μg
Conjugation Unconjugated
Physical Appearance Lyophilized Powder
Storage Buffer

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.
Reconstitution Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage

12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.

Background

Lymphocyte cytosolic protein 2 (LCP2), also commonly known as SLP-76, is a crucial adaptor protein expressed in hematopoietic cells, including T cells, B cells, macrophages, and platelets. It plays a central role in coupling activated immunoreceptors, such as the T-cell receptor (TCR), to multiple downstream signaling pathways. Upon phosphorylation, LCP2 nucleates a large signaling complex that regulates critical cellular processes including proliferation, differentiation, adhesion, and cytokine production. It is essential for proper immune cell development and function. Deficiencies in LCP2 signaling are linked to immunodeficiencies and platelet abnormalities, highlighting its fundamental importance in immunity and hemostasis.

Picture

SDS-PAGE

2μg（R: reducing conditions）