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Human LAIR1/CD305 Protein, His tag

Human LAIR1/CD305 Protein, His tag

Catalog Number: S0A1151 Brand: Starter
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$111.00 SGD
$111.00 SGD
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Product Details

Product Specification


Species Human
Synonyms Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, hLAIR1, CD305, LAIR1
Accession Q6GTX8
Amino Acid Sequence

Protein sequence (Q6GTX8, Gln22-His163, with C-His tag) QEEDLPRPSISAEPGTVIPLGSHVTFVCRGPVGVQTFRLERDSRSTYNDTEDVSQASPSESEARFRIDSVREGNAGLYRCIYYKPPKWSEQSDYLELLVKESSGGPDSPDTEPGSSAGPTQRPSDNSHNEHAPASQGLKAEH
Expression System HEK293
Molecular Weight Predicted MW: 17.2 kDa Observed MW: 30 kDa
Purity ＞95% by SDS-PAGE
Endotoxin <1EU/μg
Conjugation Unconjugated
Tag with C-His tag
Physical Appearance Lyophilized powder
Storage Buffer

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.
Reconstitution Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage

12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.

Background

LAIR1 (Leukocyte-Associated Immunoglobulin-like Receptor 1) is an inhibitory immune receptor primarily expressed on myeloid cells and lymphocytes. It regulates immune responses by transmitting inhibitory signals through immunoreceptor tyrosine-based inhibitory motifs (ITIMs) upon binding to ligands like collagen or other extracellular matrix components. LAIR1 modulates inflammation, autoimmunity, and antitumor immunity, acting as a checkpoint to prevent excessive immune activation.

Picture

SDS-PAGE

2μg（R: reducing conditions）