Flow cytometric analysis of Human PBMC labelling Human CD282 antibody at 1/200 (1 μg) dilution (Right panel) compared with a Mouse IgG2a, κ Isotype Control (Left panel). Goat Anti-Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD14 - Brilliant Violet 480™ antibody separately.
Mouse Anti-Human CD282 Antibody (S-2968)
Mouse Anti-Human CD282 Antibody (S-2968)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD282 |
| Synonyms | Toll-like receptor 2; Toll/interleukin-1 receptor-like protein 4; TIL4; TLR2 |
| Location | Membrane |
| Accession | O60603 |
| Clone Number | S-2968 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD282, also known as Toll-like receptor 2 (TLR2), is an approximately 89-kDa type I transmembrane receptor of the Toll-like receptor family that plays a pivotal role in innate immunity by recognizing pathogen-associated molecular patterns (PAMPs) such as bacterial lipoproteins and cell wall components; it cooperates with co-receptors like LY96 and forms heterodimers with TLR1 or TLR6 to activate the MYD88- and TRAF6-dependent signaling pathway, leading to NF-κB activation, cytokine secretion, and inflammatory responses, while being abundantly expressed in peripheral blood leukocytes, especially monocytes, and involved in host defense against Gram-positive bacteria and yeast.
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