Flow cytometric analysis of human peripheral blood Leukocyte labelling Human CD200R antibody at 1/200 (1 μg) dilution. Goat Anti-Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD4 - Brilliant Violet 421™ antibody separately.
Mouse Anti-Human CD276 Antibody (S-2965)
Mouse Anti-Human CD276 Antibody (S-2965)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD276 |
| Synonyms | CD276 antigen; 4Ig-B7-H3; B7 homolog 3 (B7-H3); Costimulatory molecule; B7H3 |
| Location | Membrane |
| Accession | Q5ZPR3 |
| Clone Number | S-2965 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human peripheral blood Leukocyte |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD276, also known as B7-H3, is a type I transmembrane glycoprotein belonging to the B7 family of immune co-stimulatory molecules that is broadly overexpressed on the cell surface of many solid tumors while showing only limited distribution in normal tissues; it modulates both adaptive and innate immunity by interacting with putative receptors on T cells and NK cells to either inhibit or enhance anti-tumor responses, serves as a marker for cancer progression and poor prognosis, and is actively pursued as a therapeutic target through monoclonal antibodies, antibody–drug conjugates, CAR-T cells, and bispecific T-cell engagers.
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