Flow cytometric analysis of human peripheral blood Leukocyte labelling Human CD191 antibody at 1/200 (1 μg) dilution. Goat Anti-Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD14 - Brilliant Violet 421™ antibody separately.
Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD191 |
| Synonyms | C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; CCR-1; CCR1; HM145; LD78 receptor; Macrophage inflammatory protein 1-alpha receptor (MIP-1alpha-R); RANTES-R; CMKBR1; CMKR1; SCYAR1 |
| Location | Cell membrane |
| Accession | P32246 |
| Clone Number | S-3286 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human peripheral blood Leukocyte |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD191 (officially designated CD191, also termed C-C chemokine receptor type 1, CCR1) is a 41 kDa seven-transmembrane G-protein-coupled receptor encoded by the CCR1 gene on chromosome 3p; it is predominantly expressed on monocytes, granulocytes, and a subset of T cells, where it binds the CC chemokines CCL3 (MIP-1α), CCL5 (RANTES), CCL7 (MCP-3) and CCL23 (MPIF-1) to trigger intracellular signaling that mediates chemotactic recruitment of effector leukocytes to inflammatory sites, thereby playing key roles in host defense against infection, regulation of inflammatory responses, and susceptibility to viral and parasitic pathogens.
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