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Thrombomodulin His Tag Protein, Human

Thrombomodulin His Tag Protein, Human

Catalog Number: UA010422 Reactivity: Human Conjugation: Unconjugated Brand: UA BIOSCIENCE
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$1,008 USD
$1,008 USD
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Product Details

Product Specification


Species Human
Antigen Thrombomodulin
Synonyms TM
Accession P07204
Amino Acid Sequence

Ala19-Ser515, with C-terminal 8* His

APAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLMTVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDNNTSYSRWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAVEPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIPHEPHRCQMFCNQTACPADCDPNTQASCECPEGYILDDGFICTDIDECENGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPSPTPGSTLTPPAVGLVHSGGGSHHHHHHHH
Expression System HEK293
Molecular Weight

72-83 kDa (Reducing)
Purity

＞95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Pindon A, Hantai D, Jandrot-Perrus M, Festoff BW.Novel expression and localization of active thrombomodulin on the surface ofmouse brain astrocytes. Glia 1997; 19: 259– 68.

2.Shibata M, Kumar SR, Amar A, Fernandez JA, Hofman F, Griffin JH, ZlokovicBV. Anti-inflammatory, antithrombotic, and neuroprotective effects of activatedprotein C in a murine model of focal ischemic stroke. Circulation 2001; 103:1799– 805.

Background

Thrombomodulin (TM) is a transmembrane glycoprotein located on the luminal surface of endothelial cells in most normal blood vessels that regulates coagulation and inflammation.     Encoded by an intronless gene on chromosome 20, the mature single-chain TM glycoprotein in the human is 557 amino acids long, structurally organized into five distinct regions, including the cytoplasmic and transmembrane domains, a serine/threonine-rich region with an attached chondroitin sulfate moiety, six consecutive EGF-like repeats, and the N-terminal lectin-like domain. Thrombomodulin is an endothelial cell thrombin receptor that converts thrombin into an anticoagulant capable of activating protein C, suggesting a protective role in thrombosis. TM may also affect astrocyte function and protect against thrombin-induced neuronal cell death via an APC-dependent mechanism.

Picture

SDS-PAGE

1μg (R: reducing conditions, N: non-reducing conditions).

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