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Thrombomodulin His Tag Protein, Human

Thrombomodulin His Tag Protein, Human

Catalog Number: UA010422 Brand: UA BIOSCIENCE
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$1,008 USD
$1,008 USD
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Product Details

Product Specification


Species Human
Antigen Thrombomodulin
Synonyms TM
Accession P07204
Amino Acid Sequence Ala19-Ser515, with C-terminal 8* His
Expression System HEK293
Molecular Weight

72-83 kDa (Reducing)
Purity

＞95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Pindon A, Hantai D, Jandrot-Perrus M, Festoff BW.Novel expression and localization of active thrombomodulin on the surface ofmouse brain astrocytes. Glia 1997; 19: 259– 68.

2.Shibata M, Kumar SR, Amar A, Fernandez JA, Hofman F, Griffin JH, ZlokovicBV. Anti-inflammatory, antithrombotic, and neuroprotective effects of activatedprotein C in a murine model of focal ischemic stroke. Circulation 2001; 103:1799– 805.

Background

Thrombomodulin (TM) is a transmembrane glycoprotein located on theluminal surface of endothelial cells in most normal blood vessels thatregulates coagulation and inflammation.    Encoded by an intronless gene on chromosome 20, the mature single-chainTM glycoprotein in the human is 557 amino acids long, structurally organizedinto five distinct regions, including the cytoplasmic and transmembranedomains, a serine/threonine-rich region with an attached chondroitin sulfatemoiety, six consecutive EGF-like repeats, and the N-terminal lectin-likedomain. Thrombomodulin is an endothelial cell thrombin receptor that convertsthrombin into an anticoagulant capable of activating protein C, suggesting aprotective role in thrombosis. TM may also affect astrocyte function andprotect against thrombin-induced neuronal cell death via an APC-dependentmechanism.

Picture

SDS-PAGE

1μg (R: reducing conditions, N: non-reducing conditions).