1μg (R: reducing condition, N: non-reducing condition).
PSMA/FOLH1 Fc Chimera Protein, Human
PSMA/FOLH1 Fc Chimera Protein, Human
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$316 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | GIG27, FOLH, NAALAD1, PSM, NAALADase I, GCPII, FGCP |
| Accession | Q04609-1 |
| Amino Acid Sequence | Lys44-Ala750 , with N-terminal Fc |
| Expression System | HEK293 |
| Molecular Weight | 110-140kDa (Reducing) |
| Purity | >95% by SDS-PAGE & SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Su S L. et al. (1995) Alternatively spliced variants of prostate-specific membrane antigen RNA: ratio of expression as a potential measurement of progression. Cancer Res. 55: 1441-1443. |
Background
Prostate-Specific Membrane Antigen (PSMA) is a transmembrane protein that is consistently found in prostatic tissues. Its expression is notably elevated in various malignancies, with prostate cancer exhibiting particularly high levels. In nearly all cases of prostate adenocarcinoma, PSMA is expressed in the majority of both primary and metastatic lesions.
Immunohistochemical analysis has shown that PSMA expression intensifies in patients with dedifferentiated, metastatic, or hormone-refractory tumors. The level of PSMA expression has been correlated with the prognosis of the disease, offering significant predictive value for patient outcomes.
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SDS-PAGE
SEC-HPLC
The purity of PSMA/FOLH1 Fc Chimera Protein, Human is more than 95% determined by SEC-HPLC.
ELISA
Immobilized PSMA/FOLH1 Fc Chimera Protein, Human (Cat. No. UA011064) at 2.0μg/mL (100μL/well) can bind Biotinylated Anti-Human PSMA (Rosopatamab) with EC50 of 1.59-2.42ng/mL.
