1μg (R: reducing condition, N: non-reducing condition).
PSCA Fc Chimera Protein, Mouse
PSCA Fc Chimera Protein, Mouse
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | UNQ206, PRO232,Prostate stem cell antigen |
| Accession | P57096 |
| Amino Acid Sequence | Leu21-Asn95, with N-terminal Fc |
| Expression System | HEK293 |
| Molecular Weight | 38-53kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Reiter RE, Gu Z, Watabe T, Thomas G, Szigeti K, Davis E, Wahl M, Nisitani S, Yamashiro J, Le Beau MM, Loda M, Witte ON. Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1735-40. |
Background
Prostate stem cell antigen (PSCA) is a cell-membrane glycoprotein consisting of 123 amino acids. Mouse PSCA (mPsca) shares 65% homology with human PSCA at the nucleotide and amino acid levels. Prostate Stem Cell Antigen (PSCA) is frequently expressed in prostate cancer. Knockdown of PSCA induced EMT and reduced metastatic potentials of the DU145 cells, suggesting that PSCA played an important role in prostatic carcinogenesis and progression.
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