Immobilized Human Galectin-3, His tag at 1 μg/mL (50 μL/well) can bind Galectin-3 Recombinant Rabbit mAb (SDT-370-111) (S0B2197) with EC50 of 9.036-11.94 ng/ml.
Human Galectin-3, His tag
Human Galectin-3, His tag
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | 35 kDa lectin, Carbohydrate-binding protein 35 (CBP 35), Galactose-specific lectin 3, Galactoside-binding protein (GALBP), IgE-binding prtein, LGALS3, MAC2 |
| Accession | P17931 |
| Amino Acid Sequence | Protein sequence(P17931, Ala2-Ile250, with C-10*His) |
| Expression System | E.coli |
| Molecular Weight | Theoretical: 27.8kDa Actual: 28kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
Galectin-3 is a member of the lectin family, of which 14 mammalian galectins have been identified. Galectin-3 is approximately 30 kDa and, like all galectins, contains a carbohydrate-recognition-binding domain (CRD) of about 130 amino acids that enable the specific binding of β-galactosides. Galectin-3 (Gal-3) is also a member of the beta-galactoside-binding protein family that plays an important role in cell-cell adhesion, cell-matrix interactions, macrophage activation, angiogenesis, metastasis, apoptosis. Galectin-3 is increasingly being used as a diagnostic marker for different cancers. It can be screened for and used as a prognostic factor to predict the progression of the cancer. Galectin-3 has varying effects in different types of cancer. One approach to cancers with high galectin-3 expression is to inhibit galectin-3 to enhance treatment response.
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Bioactivity
SDS-PAGE
2μg (R: reducing conditions)
