Immobilized Human ferritin/FTH1 Protein, His Tag at 4 μg/mL (50 μL/well) can bind Anti-Ferritin heavy chain 1/FTH1 Antibody, Mouse Monoclonal with EC50 of 8.877-10.05 ng/ml.
Human ferritin/FTH1 Protein, His tag
Human ferritin/FTH1 Protein, His tag
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Ferritin heavy chain, Ferritin H subunit, Cell proliferation-inducing gene 15 protein, FTH, FTHL6 |
| Accession | P02794 |
| Amino Acid Sequence | Protein sequence (P02794, Met1-Ser183, with C-His tag) MTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDCDDWESGLNAMECALHLEKNVNQSLLELHKLATDKNDPHLCDFIETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLGDSDNES |
| Expression System | E.coli |
| Molecular Weight | Predicted MW: 22.9 kDa Observed MW: 24 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | with C-His tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
Ferritin heavy chain is a ferroxidase enzyme that in humans is encoded by the FTH1 gene. FTH1 gene is located on chromosome 11, and its mutation causes Hemochromatosis type 5. This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. Plasma ferritin is also an indirect marker of the total amount of iron stored in the body; hence, serum ferritin is used as a diagnostic test for iron-deficiency anemia. Aggregated ferritin transforms into a toxic form of iron called hemosiderin.
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Bioactivity
SDS-PAGE
2 μg（R: reducing conditions）
