2μg (R: reducing condition, N: non-reducing condition).
Biotinylated VSIG4 Fc&Avi Tag Protein, Human
Biotinylated VSIG4 Fc&Avi Tag Protein, Human
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$560 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | V-set and immunoglobulin domain-containing protein 4, Protein Z39Ig, Z39IG, CRIg |
| Accession | Q9Y279-1 |
| Amino Acid Sequence | Arg20-Pro283 with Human IgG1 Fc & Avi Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 70-75kDa (Reducing) |
| Purity | >95% by SDS-PAGE & RP-HPLC |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag, Avi Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Pan W, Huang W, Zheng J, Meng Z, Pan X. Construction of a prognosis model of head and neck squamous cell carcinoma pyroptosis and an analysis of immuno-phenotyping based on bioinformatics. Transl Cancer Res. 2024 Jan 31;13(1):299-316. |
Background
VSIG4 (V-set and immunoglobulin domain containing 4), also known as CRIg and Z39IG, is a type I transmembrane protein belonging to the B7 family within the immunoglobulin (Ig) superfamily. It features two Ig-like domains. VSIG4 is highly expressed in various fetal tissues, with the highest levels observed in the lung and placenta of adult tissues.
VSIG4 serves as a negative regulator of T cell activation and is believed to play a role in maintaining peripheral T cell tolerance. Additionally, it has been identified as a potent suppressor of established inflammation. The protein acts as a phagocytic receptor and exerts a strong inhibitory effect on T-cell proliferation and IL-2 production.
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SDS-PAGE
RP-HPLC
The purity of Biotinylated VSIG4 Fc&Avi Tag Protein, Human is more than 95% determined by RP-HPLC.
ELISA
Immobilized human iC3b at 5μg/mL (100μL/well) can bind Biotinylated VSIG4 Fc&Avi Tag Protein, Human(Cat. No. UA011000) with EC50 of 11.82-13.78 ng/mL.
