1μg (R: reducing condition, N: non-reducing condition).
Biotinylated KIR2DL5/CD158f Fc&Avi Tag Protein, Human
Biotinylated KIR2DL5/CD158f Fc&Avi Tag Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | CD158f |
| Accession | Q8N109 |
| Amino Acid Sequence | His22-His240, with C-terminal hIgG1 Fc and Avitag |
| Expression System | HEK293 |
| Molecular Weight | 65-72kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Estefania, E. et al. (2007) J. Immunol. 178:4402. 2.Lanier, L. L. (2005) Annu. Rev. Immunol. 23:225. |
Background
Killer cell immunoglobulin-like receptor 2DL5(KIR2DL5), which belongs to the immunoglobulin superfamily, is an inhibitory receptor of NK cells.KIR2DL5 (CD158f) is the most recently identified inhibitory member of human killer-cell Ig-like receptors (KIRs), which enable NK cells to sense self-HLA.KIR2DL5 is encoded by two paralogous genes displaying copy number variation and allelic polymorphism-KIR2DL5A and KIR2DL5B. Functional polymorphisms in both its promoter and its coding regions are critical for understanding the KIR2DL5 role in immunity and its importance for human health.
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