1μg (R: reducing condition, N: non-reducing condition).
uPAR/CD87 His Tag Protein, Human
uPAR/CD87 His Tag Protein, Human
Price:
Regular price
$240 USD
Regular price
Sale price
$240 USD
Unit price
per
For shipping services or bulk orders, you may request a quotation.
Secure checkout with
View full details
Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Monocyte activation antigen Mo3, U-PAR, uPAR, Urokinase-Type Plasminogen Activator (UPA) Receptor, URKR, U-Plasminogen Activator Receptor Form 2, CD87 Antigen, Plasminogen Activator, Urokinase Receptor, MO3 |
| Accession | Q03405 |
| Amino Acid Sequence | Leu23-Gly305 with His Tag at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 43-55kDa (Reducing) |
| Purity | > 95% by SDS-PAGE &RP-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Desmedt, S. et al. (2017) Crit. Rev. Clin. Lab. Sci. 54:117.2.Smith, H. et al. (2010) Nat Rev Mol Cell Biol 11:23. |
Background
Urokinase plasminogen activator surface receptor (U-PAR), also known as PLAUR, Monocyte activation antigen Mo3, or CD87, is a key player in cellular processes involving migration and tissue remodeling. It binds to urokinase-type plasminogen activator (uPA), which converts plasminogen to plasmin, a serine protease essential for normal and pathological cell migration and tissue destruction. uPA is initially released as a single-chain pro-enzyme (scuPA) with low activity and is activated to a two-chain form (tcuPA) by plasmin and other proteinases. Both forms of uPA bind to uPAR, localizing uPA's proteolytic activity and enhancing its enzymatic activity.The uPA/uPAR interaction initiates signal transduction, activating protein tyrosine kinases, influencing gene expression, and promoting cell adhesion and chemotaxis. uPAR can also modulate integrin function, suppressing normal adhesion while enhancing vitronectin binding through its high-affinity site. This interaction is significant in various inflammatory diseases, including cancer, cardiovascular diseases, chronic kidney diseases, and diabetes, making uPAR a potential biomarker for these conditions
Picture
Picture
SDS-PAGE
RP-HPLC
The purity of uPAR/CD87 His Tag Protein, Human more than 95% as determined by RP-HPLC.
SPR
CM5 Chip captured uPAR/CD87 His Tag Protein, Human (Cat. No. UA010519), can bind Human PLAU / uPA Protein, His Tag with an affinity constant of 0.12nM as determined in SPR assay.
