SH-SY5Y Cell Lysate
SH-SY5Y Cell Lysate
Product Details
Product Details
Product Specification
| Host | Human |
| Concentration | 2 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | Supplied in SDS Sample Buffer: 50 mM Tris-HCl (pH 6.8 at 25°C), 2% w/v SDS, 10% glycerol, 1% v/v β-Mercaptoethanol, 0.01% w/v bromophenol blue |
| Stability & Storage | -20 °C for 1 months under sterile conditions; |
Background
SH-SY5Y cells are subclones derived from the human neuroblastoma cell line SK-N-SH and represent a classic in vitro model in neuroscience research. They possess the following key characteristics: • Semi-adherent growth with tendency to aggregate, leading to insufficient lysis using conventional lysis buffers. • High expression of neuronal marker proteins including tyrosine hydroxylase (TH), microtubule-associated protein 2 (MAP2), and α‑synuclein. • Sensitivity to neurotoxins, making them widely used in studies of Parkinson’s disease, neuronal differentiation, drug screening, and tumor mechanisms.
