Bc1-w His Tag Protein, Human

Catalog Number: UA011025 Reactivity: Human Conjugation: Unconjugated Brand: UA BIOSCIENCE

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$148 USD

Size: 10μg 50μg

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Product Details

Product Specification

Species	Human
Synonyms	Bcl-2-Like Protein 2; Bcl2-L-2; Apoptosis Regulator Bcl-W; BCL2L2; BCLW; KIAA0271
Accession	AAI13523.1
Amino Acid Sequence	Ala2-Thr172
Expression System	E.coli
Molecular Weight	19.87 KDa
Purity	＞95% by SDS-PAGE
Endotoxin	<1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Liquid
Storage Buffer	25mM HEPES, 100mM KCl, 20% Glycerol, pH 7.5.
Stability & Storage	Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

Background

Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing three motifs, BH1, BH2 and BH4. The BH4 motif appears to be involved in the anti-apoptotic function. The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. BCL2L2 promotes cell survival and blocks dexamethasone-induced apoptosis. Furthermore, BCL2L2 mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.

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Bc1-w His Tag Protein, Human