IHC shows positive staining in paraffin-embedded human kidney. Anti- B7-H6 antibody was used at 1/2000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
B7-H6 Recombinant Rabbit mAb, PBS Only (SDT-3241-6)
B7-H6 Recombinant Rabbit mAb, PBS Only (SDT-3241-6)
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Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | B7-H6 |
| Synonyms | Natural cytotoxicity triggering receptor 3 ligand 1; B7 homolog 6 (B7-H6); B7H6; NCR3LG1 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | Q68D85 |
| Clone Number | SDT-3241-6 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P |
| Reactivity | Hu |
| Predicted Reactivity | Or |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000-1:2000 | Hu |
Background
B7-H6, also known as NCR3LG1, is a type I transmembrane glycoprotein of the B7 family that selectively engages the activating NK cell receptor NKp30 to trigger natural killer (NK) cell cytotoxicity and cytokine release; it is virtually absent from normal adult tissues but is frequently up-regulated on a wide spectrum of hematologic and solid tumors, where its expression correlates with enhanced NK-mediated lysis and serves as an independent prognostic biomarker linked to tumor differentiation, recurrence, and patient survival.
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Immunohistochemistry
Negative control: IHC shows negative staining in paraffin-embedded human cerebral cortex. Anti- B7-H6 antibody was used at 1/2000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human colon cancer. Anti- B7-H6 antibody was used at 1/2000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human thyroid cancer. Anti- B7-H6 antibody was used at 1/2000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
