Flow cytometric analysis of Mouse MERTK expression on C57BL/6 mouse peritoneal exudates cells. C57BL/6 mouse peritoneal exudates cells were stained with FITC Rat Anti-Mouse F4/80 Antibody (S0B5113) at 5μl/test and either APC Rat IgG2a, κ Isotype Control (Left panel) or SDT APC Rat Anti-Mouse MERTK Antibody (Right panel) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
APC Rat Anti-Mouse MERTK Antibody (S-R603)
APC Rat Anti-Mouse MERTK Antibody (S-R603)
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | MERTK |
| Synonyms | Tyrosine-protein kinase Mer; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK; Mer; Mertk |
| Location | Cell membrane |
| Accession | Q60805 |
| Clone Number | S-R603 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse peritoneal exudates cells |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
MERTK, also known as MER proto-oncogene tyrosine kinase, is a receptor tyrosine kinase and a member of the TAM (TYRO3, AXL, MERTK) family. It plays crucial roles in various physiological processes, including cell survival, migration, differentiation, and the phagocytosis of apoptotic cells, a process known as efferocytosis. MERTK is expressed in multiple tissues, such as macrophages and retinal pigment epithelial cells, and is involved in regulating immune responses and maintaining tissue homeostasis. In the immune system, MERTK helps macrophages clear apoptotic cells and inhibits the innate immune response by activating STAT1, which induces the production of suppressors of cytokine signaling (SOCS1 and SOCS3). Abnormal expression of MERTK has been linked to several diseases, including retinitis pigmentosa and certain cancers, making it a potential therapeutic target in cancer treatment.
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