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APC Mouse Anti-Human CD62P Antibody (S-921-3)

APC Mouse Anti-Human CD62P Antibody (S-921-3)

Catalog Number: S0B5047 Application: FCM Reactivity: Human Conjugation: APC Brand: Starter
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Regular price $65.00 SGD
Regular price Sale price $65.00 SGD
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Product Details

Product Specification


Host Mouse
Antigen CD62P
Synonyms P-selectin; CD62 antigen-like family member P; Granule membrane protein 140 (GMP-140); Leukocyte-endothelial cell adhesion molecule 3 (LECAM3); Platelet activation dependent granule-external membrane protein (PADGEM); SELP; GMRP; GRMP
Immunogen Recombinant Protein
Location Cell membrane
Accession P16109
Clone Number S-921-3
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample human PBMC
Purification Protein G
Concentration 0.05mg/ml
Conjugation APC
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

CD62P is a type-1 transmembrane protein that in humans is encoded by the SELP gene. It functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called Weibel-Palade bodies. CD62P plays an essential role in the initial recruitment of leukocytes (white blood cells) to the site of injury during inflammation. When endothelial cells are activated by molecules such as histamine or thrombin during inflammation, CD62P moves from an internal cell location to the endothelial cell surface. P-selectin is also very important in the recruitment and aggregation of platelets at areas of vascular injury. CD62P has a functional role in tumour metastasis similar to E-selectin. CD62P is expressed on the surface of both stimulated endothelial cells and activated platelets, and helps cancer cells invade into the bloodstream for metastasis and provides local multiple growth factors, respectively.

Picture

FC

Flow cytometric analysis of Human CD62P expression on human PBMC (human peripheral blood mononuclear cells). Human PBMC were stained with Alexa Fluor® 488 Mouse Anti-Human CD42b Antibody at 5μl/test (S0B1672) and either APC Mouse IgG1, κ Isotype Control (Left panel) or SDT APC Mouse Anti-Human CD62P (Right panel) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.

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