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Mouse Anti-Human CXCR6 Antibody (S-3884)

Mouse Anti-Human CXCR6 Antibody (S-3884)

Catalog Number: S0B8824 Application: FCM Reactivity: Human Conjugation: Unconjugated Brand: Starter
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Regular price $110 USD
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Product Details

Product Specification


Host Mouse
Antigen CXCR6
Synonyms C-X-C chemokine receptor type 6; CXC-R6; CXCR-6; CDw186; G-protein coupled receptor STRL33; G-protein coupled receptor bonzo; CD186; BONZO; STRL33; TYMSTR
Location Cell membrane
Accession O00574
Clone Number S-3884
Antibody Type Mouse mAb
Isotype IgG2a,k
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Purification Protein A
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1:200 Hu

Background

CXCR6 (C-X-C motif chemokine receptor 6), also known as STRL33 and T-lymphocyte-expressed seven-transmembrane domain receptor (TYMSTR), is a G protein-coupled receptor (GPCR) that specifically binds to its unique ligand CXCL16, a transmembrane chemokine that can also be cleaved to function as a soluble chemokine. CXCR6 is predominantly expressed on memory/effector T cells, natural killer T (NKT) cells, natural killer (NK) cells, and plasma cells, playing critical roles in immune cell trafficking, adhesion, and activation. The CXCR6-CXCL16 axis is essential for the recruitment and positioning of immune cells in various tissues, particularly in the liver, spleen, and inflamed sites, and has been implicated in numerous pathological conditions including chronic inflammation, autoimmune diseases, infectious diseases, and cancer. In oncology, CXCR6 expression on tumor-infiltrating lymphocytes (TILs) is associated with improved prognosis in certain cancers, while its expression on tumor cells can promote metastasis and disease progression. The receptor signals primarily through Gαi proteins, activating downstream pathways such as PI3K/AKT, MAPK/ERK, and calcium mobilization, thereby regulating cell migration, survival, and proliferation. Given its selective expression on activated immune cells and its involvement in disease pathogenesis, CXCR6 represents an attractive therapeutic target for immunomodulatory strategies and precision medicine approaches.

Picture

FC

Flow cytometric analysis of human PBMC (human peripheral blood mononuclear cells) labelling Mouse Anti-Human CXCR6 antibody at 1/200 dilution (1 μg) / (right panel) compared with a Mouse IgG2a, κ Isotype Control / (left panel). Goat Anti-Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD3 - Brilliant Violet 421™ antibody separately. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.