Human E-Selectin/CD62E OneStep ELISA Kit

E-selectin (also known as CD62E, ELAM-1, or SELE) is a type I transmembrane glycoprotein belonging to the selectin family of cell adhesion molecules. It is exclusively expressed on activated vascular endothelial cells in response to inflammatory cytokines such as IL-1β and TNF-α. Unlike P-selectin, which is pre-stored in Weibel-Palade bodies, E-selectin requires de novo gene transcription and protein synthesis. It is a cell adhesion glycoprotein exclusively expressed on activated vascular endothelial cells during inflammation, mediating the initial rolling and tethering of leukocytes via calcium-dependent recognition of sialyl Lewis X/Lewis A glycans. Beyond its central role in leukocyte trafficking, E-selectin is implicated in tumor metastasis, angiogenesis, and immune regulation. Soluble E-selectin serves as a clinical biomarker for endothelial activation in cardiovascular disease, sepsis, and autoimmune disorders. Consequently, E-selectin proteins are indispensable tools for both fundamental mechanistic studies and the development of diagnostic or therapeutic strategies targeting pathological inflammation and cancer spread.