Flow cytometric analysis of PHA-activated (2 days) human PBMC labelling CD152 antibody at 1/200 dilution (1 μg) / (Right panel) compared with a Mouse IgG2a, κ Isotype Control / (Left panel). Goat Anti-Mouse IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD3 - Brilliant Violet 421™ Antibody separately.
Mouse Anti-Human CD152 Antibody (S-R577)
Mouse Anti-Human CD152 Antibody (S-R577)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD152 |
| Synonyms | Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4); CTLA4 |
| Location | Cell membrane |
| Accession | P16410 |
| Clone Number | S-R577 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | ICFCM |
| Reactivity | Hu |
| Positive Sample | PHA-activated (2 days) human PBMC |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD152, also known as CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), is a protein receptor that functions as an immune checkpoint. It is a member of the immunoglobulin superfamily and is expressed on the surface of T cells. The CD152 gene consists of 4 exons and encodes a protein with a signal peptide, an Ig-like domain, a transmembrane region, and a cytoplasmic domain. CD152 plays an essential role in regulating T cell activation by binding to its ligands CD80 and CD86, which are expressed on antigen-presenting cells. This binding can inhibit the over-activation of T cells, thus maintaining immune homeostasis.
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